Mercedes-Benz S 450 4MATIC vs Mercedes-Benz AMG E 43 — full comparison

Mercedes-Benz S 450 4MATIC

Sedan · Gasoline · AWD

vs

Mercedes-Benz AMG E 43

Sedan · Gasoline · FWD

Mercedes-Benz S 450 4MATIC

Car A

Mercedes-Benz S 450 4MATIC

The Mercedes-Benz S 450 4MATIC pairs strong AWD performance with room for five, making it well-suited to road trips and winter use. It offers good value in its segment given its 362 hp, 5.4 s 0–100 km/h, and a usable 525 L trunk.

5 seatsSedanGasoline5-star safetyAWD

Mercedes-Benz AMG E 43

Car B

Mercedes-Benz AMG E 43

The Mercedes-Benz AMG E 43 blends serious V6 biturbo pace with five-seat practicality and a generous 540 L trunk for premium-minded travelers. It’s quick yet reasonably efficient for its class at 9 L/100 km.

5 seatsSedanGasoline5-star safety9 L/100km396 hp

Why compared same body typesame brandsame powertrainsame seatssimilar price

Usage fit

Family 55 / 63

City 31 / 29

Budget / value 32 / 40

Road trip 69 / 63

Performance 43 / 36

Cargo 29 / 30

Practical 30 / 41

Premium 61 / 65

Winter 70 / 30

Scores out of 100. Blue = Mercedes-Benz S 450 4MATIC · Orange = Mercedes-Benz AMG E 43

Specs side-by-side

Spec Mercedes-Benz S 450 4MATIC Mercedes-Benz AMG E 43

Values are representative — confirm for your market and trim.

Pros & cons

Mercedes-Benz S 450 4MATIC

AWD traction boosts confidence for winter driving and long-distance trips.
Strong performance (362 hp, 500 Nm, 0–100 km/h in 5.4 s) for easy passing and highway cruising.
Seats five with a 525 L trunk, fitting family travel and weekend luggage.
High safety ranking in the signals adds peace of mind.
Combined consumption of 9.2 L/100 km won’t suit efficiency-first buyers.
Five seats only; no third row for larger families.
Trunk layout limits bulky, cargo-heavy use compared with more flexible body styles.
Price of 60000 may still exceed tighter budgets despite strong value signals.

Mercedes-Benz AMG E 43

Explosive acceleration (0–100 km/h in 4.6 s) backed by a 396‑hp V6 biturbo.
Five seats and a 540 L trunk suit road trips and growing families.
Signals indicate strong standing for horsepower and safety in its segment.
9 L/100 km combined is efficient for its class given the performance.
Front‑wheel drive may disappoint buyers wanting all‑wheel‑drive traction.
At 72,600, it sits well above mainstream price points.
Usage signals suggest it’s less at home in stop‑start city driving.
Despite a big trunk, it isn’t ideal for cargo‑heavy or bulky loads.

Verdict

Pick Mercedes-Benz S 450 4MATIC if…

Lower entry price

Mercedes-Benz S 450 4MATIC starts lower, making it the stronger value pick if budget is a priority.

Pick Mercedes-Benz AMG E 43 if…

More power

Mercedes-Benz AMG E 43 puts out 396 hp vs 362 — meaningfully quicker and more confident on motorways.

Related comparisons