Mercedes-Benz E 350 vs Audi A6 4.0 TFSI — full comparison

Mercedes-Benz E 350

Sedan · Gasoline · FWD

vs

Audi A6 4.0 TFSI

Sedan · Gasoline · AWD

Mercedes-Benz E 350

Car A

Mercedes-Benz E 350

The Mercedes-Benz E 350 blends strong performance with family-ready space, making it well-suited to growing families and long trips. Efficiency is solid for its class at 8 L/100 km, though the FWD layout may lessen winter appeal.

5 seatsSedanGasoline5-star safety8 L/100km

Audi A6 4.0 TFSI

Car B

Audi A6 4.0 TFSI

A powerful AWD premium A6 with 560 hp and a strong safety ranking, it pairs rapid acceleration with space for five and a 530-liter trunk for long trips. Expect higher fuel use and a price aimed at buyers who prioritize performance.

5 seatsSedanGasoline5-star safety560 hpAWD

Why compared same body typesame powertrainsame ranking profilesame seatsstrong ranking match

Usage fit

Family 64 / 63

City 33 / 24

Budget / value 49 / 33

Road trip 63 / 70

Performance 36 / 50

Cargo 30 / 29

Practical 44 / 41

Premium 61 / 72

Winter 30 / 70

Scores out of 100. Blue = Mercedes-Benz E 350 · Orange = Audi A6 4.0 TFSI

Specs side-by-side

Spec Mercedes-Benz E 350 Audi A6 4.0 TFSI

Values are representative — confirm for your market and trim.

Pros & cons

Mercedes-Benz E 350

Quick acceleration and strong passing power from 320 hp and a 5.9 s 0–100 km/h
Five seats and a 540 L trunk suit family duties and road-trip luggage
Efficient for its class at 8 L/100 km for a gasoline powertrain
Good value in its segment at this price point given its performance and space
Front-wheel drive may not satisfy buyers seeking extra winter traction
If you often carry oversized or bulky items, the trunk may be limiting
At 8 L/100 km, there are more efficient options if fuel economy is your top priority
The price may feel high if you don’t need this level of performance

Audi A6 4.0 TFSI

High-output V8 twin-turbo performance (560 hp, 700 Nm) with a quick 0–100 in 4.4 s
AWD traction boosts confidence on wet or winter roads
Seats five and offers a 530 L trunk for road trips and growing families
Strong safety ranking signal for its profile
Combined consumption of 10.1 leads to higher running costs
Less suited to stop-and-go city driving per usage signals
Conventional trunk limits flexibility for cargo-heavy use despite 530 L capacity
87,000 price may exceed budgets if you don’t need this level of power

Verdict

Pick Mercedes-Benz E 350 if…

Best fuel economy

Mercedes-Benz E 350 uses 8.0 L/100km vs 10.1 — a meaningful saving if you cover high mileage.

Pick Audi A6 4.0 TFSI if…

All-wheel drive

Audi A6 4.0 TFSI's AWD adds real-world confidence in wet, icy, or mixed-weather conditions.

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