Audi S4 Sedan vs Mercedes-Benz E 350

Audi S4 Sedan

Sedan · Gasoline · AWD

Mercedes-Benz E 350

Sedan · Gasoline · FWD

Car A

Audi S4 Sedan

The Audi S4 Sedan pairs strong V6 power and AWD traction with five-seat practicality, making it a confident choice for growing families and road trips. It delivers quick acceleration and efficient-for-its-class consumption, though cargo space and track-day performance aren’t its focus.

5 seatsSedanGasoline5-star safety7.4 L/100km354 hpAWD

Car B

Mercedes-Benz E 350

The Mercedes-Benz E 350 blends strong performance with family-ready space, making it well-suited to growing families and long trips. Efficiency is solid for its class at 8 L/100 km, though the FWD layout may lessen winter appeal.

5 seatsSedanGasoline5-star safety

Why compared cross brandsame body typesame powertrainsame seatssame usage profilesimilar price

Usage fit

Family 63 / 64

City 47 / 33

Budget / value 55 / 49

Road trip 57 / 63

Performance 40 / 36

Cargo 26 / 30

Practical 44 / 44

Premium 53 / 61

Winter 66 / 30

Scores out of 100. Blue = Audi S4 Sedan · Orange = Mercedes-Benz E 350

Specs side-by-side

Spec Audi S4 Sedan Mercedes-Benz E 350

Values are representative — confirm for your market and trim.

Pros & cons

Audi S4 Sedan

Strong V6 output (354 hp, 500 Nm) with 4.6 s 0–100 km/h for confident passing
AWD traction adds assurance in winter and mixed conditions
Five seats and a 480 L trunk fit growing-family and road-trip needs
Efficient for its class at 7.4 combined and good value in its segment
Sedan body and 480 L trunk limit cargo flexibility versus SUVs and wagons
Not aimed at hardcore performance driving despite its power
No third-row option; seats five only
Price around 53,000 may stretch tighter budgets

Mercedes-Benz E 350

Quick acceleration and strong passing power from 320 hp and a 5.9 s 0–100 km/h
Five seats and a 540 L trunk suit family duties and road-trip luggage
Efficient for its class at 8 L/100 km for a gasoline powertrain
Good value in its segment at this price point given its performance and space
Front-wheel drive may not satisfy buyers seeking extra winter traction
If you often carry oversized or bulky items, the trunk may be limiting
At 8 L/100 km, there are more efficient options if fuel economy is your top priority
The price may feel high if you don’t need this level of performance

Verdict

Pick Audi S4 Sedan if…

Best fuel economy

Audi S4 Sedan uses 7.4 L/100km vs 8.0 — a meaningful saving if you cover high mileage.

Pick Mercedes-Benz E 350 if…

Performance & capability

Mercedes-Benz E 350 is the choice if you want more power, speed, or all-weather capability.

Usage fit

Specs side-by-side

Pros & cons

Audi S4 Sedan

Mercedes-Benz E 350

Verdict

Related comparisons